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Product Image-SHBT100-195-500UG

Human Recombinant IL-1RA (from E. coli)

Supplier: Shenandoah Biotechnology
Description: Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.

Product Image-SHBT100-19-500UG

Human Recombinant RANK LIGAND (from E. coli)

Supplier: Shenandoah Biotechnology
Description: Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.

Image Unavailable-PRSI33-054

Anti-MYD88 Rabbit Polyclonal Antibody

Catalog Number: (PRSI33-054)
Supplier: ProSci Inc.
Description: MYD88 (myeloid differentiation primary response 88) is an essential signal transducer in the IL-1R and Toll-like receptor signaling pathways which regulate activation of numerous proinflammatory genes. Activated TLR signaling via MYD88 ultimately leads to IKK activation, IkB degradation and NF-kB mediated signaling.
UOM: 1 * 100 µG
Image Unavailable-1A02710

Cisatracurium Besylate cis-Quaternary Acid (COLD SHIPMENT REQUIRED) (25 mg) ((1R,2R)-2-(2-carboxyethyl)-1-(3,4-dimethoxybenzyl)-6,7- dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-iumbenzenesulfonate) 1 * 25 mg

Catalog Number: (1A02710)
Supplier: USP
Description: Cisatracurium Besylate cis-Quaternary Acid (COLD SHIPMENT REQUIRED) (25 mg) ((1R,2R)-2-(2-carboxyethyl)-1-(3,4-dimethoxybenzyl)-6,7- dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-iumbenzenesulfonate) 1 * 25 mg
UOM: 1 * 25 mg

New Product


Image Unavailable-1A03910

Vilanterol Diamine Triphenylacetate (25 mg) (4,4'-((1R,1'R)-((oxybis(hexane-6,1-diyl))bis(azanediyl))bis(1-hydroxyethane-2,1-diyl))b is(2-(hydroxymethyl)phenol), 2,2,2-triphenylacetate)) 1 * 25 mg

Catalog Number: (1A03910)
Supplier: USP
Description: Vilanterol Diamine Triphenylacetate (25 mg) (4,4'-((1R,1'R)-((oxybis(hexane-6,1-diyl))bis(azanediyl))bis(1-hydroxyethane-2,1-diyl))b is(2-(hydroxymethyl)phenol), 2,2,2-triphenylacetate)) 1 * 25 mg
UOM: 1 * 25 mg

New Product


Image Unavailable-1A02880

Atracurium Iodide Quaternary Alcohol Acetate (25 mg) ((1R)-2-(3-((5-acetoxypentyl)oxy)-3-oxopropyl)-1-(3,4-dimethoxybenzyl)-6,7-dime thoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium, iodide) 1 * 25 mg

Catalog Number: (1A02880)
Supplier: USP
Description: Atracurium Iodide Quaternary Alcohol Acetate (25 mg) ((1R)-2-(3-((5-acetoxypentyl)oxy)-3-oxopropyl)-1-(3,4-dimethoxybenzyl)-6,7-dime thoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium, iodide) 1 * 25 mg
UOM: 1 * 25 mg

New Product


Product Image-PRSI3129

Anti-TRAF6 Rabbit Polyclonal Antibody

Catalog Number: (PRSI3129)
Supplier: ProSci Inc.
Description: TRAF6 Antibody: Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-kappa B. TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families. TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands. It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) or by other TLR adaptor molecules such as TRIF. Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK.
UOM: 1 * 100 µG
Image Unavailable-1A02050

Isotachysterol3 (25 mg) (COLD SHIPMENT REQUIRED) (S)-4-methyl-3-((E)-2-((1R,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)-2,3,5,6,7,7a- hexahydro-1H-inden-4-yl)vinyl)cyclohex-3-en-1-ol) 1 * 25 mg

Catalog Number: (1A02050)
Supplier: USP
Description: Isotachysterol3 (25 mg) (COLD SHIPMENT REQUIRED) (S)-4-methyl-3-((E)-2-((1R,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)-2,3,5,6,7,7a- hexahydro-1H-inden-4-yl)vinyl)cyclohex-3-en-1-ol) 1 * 25 mg
UOM: 1 * 25 mg

New Product


Image Unavailable-1477590.

[Lys(Ac)]5-Octreotide (10 mg) (D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-N6-acetyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydr oxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2-->7)-disulfide) 1 * 10 mg

Catalog Number: (1477590.)
Supplier: USP
Description: [Lys(Ac)]5-Octreotide (10 mg) (D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-N6-acetyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydr oxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2-->7)-disulfide) 1 * 10 mg
UOM: 1 * 10 mg

New Product


Image Unavailable-1609864.

Saxagliptin Related Compound B (15 mg) (Saxagliptin amide analog (1S,3S,5S)-2-{(S)-2-Amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl] acetyl}-2-azabicyclo[3.1.0]hexane-3-carboxamide) 1 * 15 mg

Catalog Number: (1609864.)
Supplier: USP
Description: Saxagliptin Related Compound B (15 mg) (Saxagliptin amide analog (1S,3S,5S)-2-{(S)-2-Amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl] acetyl}-2-azabicyclo[3.1.0]hexane-3-carboxamide) 1 * 15 mg
UOM: 1 * 15 mg

New Product


Product Image-PRSI2123

Anti-IRAK2 Rabbit Polyclonal Antibody

Catalog Number: (PRSI2123)
Supplier: ProSci Inc.
Description: IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa B activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.
UOM: 1 * 100 µG
Product Image-PRSI2213

Anti-IRAK2 Rabbit Polyclonal Antibody

Catalog Number: (PRSI2213)
Supplier: ProSci Inc.
Description: IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.
UOM: 1 * 100 µG
Image Unavailable-1370892.

Lurasidone Related Compound C (15 mg) ((3aR,4R,7S,7aS)-2-{(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethy l}hexahydro-4,7-methano-2H-isoindole-1,3-dione, hydrochloride) 1 * 15 mg

Catalog Number: (1370892.)
Supplier: USP
Description: Lurasidone Related Compound C (15 mg) ((3aR,4R,7S,7aS)-2-{(1R,2R)-2-[4-(1,2-Benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethy l}hexahydro-4,7-methano-2H-isoindole-1,3-dione, hydrochloride) 1 * 15 mg
UOM: 1 * 15 mg

New Product


Image Unavailable-1A04960

endo-Lurasidone (25 mg) ((3aR,4R,7S,7aS)-2-{[1R,2R]-2-[4-(1,2-benzisothiazol-3-yl)-piperazin-1-yl-methyl]-cyclohexyl methyl}hexahydr o-4,7-methano-2H-isoindole-1,3-dione) 1 * 25 mg

Catalog Number: (1A04960)
Supplier: USP
Description: endo-Lurasidone (25 mg) ((3aR,4R,7S,7aS)-2-{[1R,2R]-2-[4-(1,2-benzisothiazol-3-yl)-piperazin-1-yl-methyl]-cyclohexyl methyl}hexahydr o-4,7-methano-2H-isoindole-1,3-dione) 1 * 25 mg
UOM: 1 * 25 mg

New Product


Image Unavailable-1609873.

Saxagliptin Related Compound C (15 mg) ((1aS,4S,6aR,7aS)-4-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]hexahydro-1H-cyclopropa[4,5]pyrrol o[1,2-a]pyrazine-3,6-dione) 1 * 15 mg

Catalog Number: (1609873.)
Supplier: USP
Description: Saxagliptin Related Compound C (15 mg) ((1aS,4S,6aR,7aS)-4-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]hexahydro-1H-cyclopropa[4,5]pyrrol o[1,2-a]pyrazine-3,6-dione) 1 * 15 mg
UOM: 1 * 15 mg

New Product


Product Image-SHBT200-81AF-100UG

Mouse Recombinant IL-36 gamma (Animal free) (from E. coli)

Supplier: Shenandoah Biotechnology
Description: Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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