TriLink® N1-Methyl-Pseudouridine-5'-Triphosphate

Supplier: TriLink BioTechnologies

N-1081-10 N-1081-1 N-1081-100 N-1081-5
SOLUN-1081-10EA 430 GBP
SOLUN-1081-10 SOLUN-1081-1 SOLUN-1081-100 SOLUN-1081-5
TriLink® N1-Methyl-Pseudouridine-5'-Triphosphate
Nucleic Acid Reagents Nucleotides

N1-Methyl-Pseudouridine-5'-Triphosphate is widely used in mRNA synthesis for therapeutic and vaccine development to improve mRNA functionality. This nucleotide consists of a modified base, a ribose, and a 5′ triphosphate group.


  • Reduces mRNA immunostimulatory effects

  • Improves mRNA translation efficiency

  • Enhances mRNA stability

  • ≥99% purity by AX-HPLC analysis

  • Provided as 100 mM in H₂O, pH 7,5

  • Grade: RUO


N1-Methylpseudouridine-5'-Triphosphate (N1MePsU) is a modified NTP for incorporation into messenger RNAs (mRNA) using an enzyme such as T7 RNA Polymerase. Modified uridines such as N1-methylpseudouridine, 5-methoxyuridine, and pseudouridine can reduce unwanted immunogenic response and enhance translational efficiency of mRNAs. These properties can result in safer mRNA and increased protein expression.


Caution: Item will be delivered at or below −20 °C and should be stored at or below −20 °C.

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