Aurintricarboxylic acid ≥85%, powder, Practical grade for titration, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY


M-Clarity™ quality level = MQ300

A1895-25G A1895-5G
A1895-25GEA 277 GBP
A1895-25G A1895-5G
Aurintricarboxylic acid ≥85%, powder, Practical grade for titration, Sigma-Aldrich®
Aurintricarboxylic acid

Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.


  • Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum
  • It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase)
  • It has been used as a ribonuclease inhibitor

Formula: C₂₂H₁₄O₉
MW: 422,35 g/mol
Melting Pt: 300 °C (lit.)
Storage Temperature: Room Temperature
MDL Number: MFCD00011663
CAS Number: 4431-00-9
EINECS: 224-628-1
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Specification Test Results

Red to Very Dark Red and Red-Brown and Brown-Red Appearance (Colour)
Appearance (Form) Powder
Solubility (Colour) Faint Orange to Red-Brown
Solubility (Turbidity), 10 mg/mL, 1M NH4OH Clear
Infrared spectrum Conforms to Structure
Loss on Drying ≤5 %
Purity (Titration by NaOH) ≥85 %
Recommended Retest Period 6 Years

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