Irinotecan hydrochloride trihydrate ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: CPT-11, Irinotecan HCl Trihydrate, (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate

ALX430139M005 ALX430139M025
ENZOALX430139M005EA 131 GBP
ENZOALX430139M005 ENZOALX430139M025
Irinotecan hydrochloride trihydrate ≥98% (by HPLC)
Irinotecan hydrochloride trihydrate

Topoisomerase I inhibitor


A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

Formula: C₃₃H₃₈N₄O₆·HCl·3H₂O
MW: 677,19 g/mol (623,15 anhy)
MDL Number: MFCD01765731
CAS Number: 136572-09-3

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