YC-1 ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
(5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)methanol, Lificiguat
Guanylyl cyclase activator
Nitric oxide (NO) independent, superoxide-sensitive stimulator of soluble guanylyl cyclase (sGC), EC50=18.6μM. Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. Non-specific phosphodiesterase inhibitor. YC-1 inhibits HIF-alpha activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na+ channel.Binds to [3H]BW202W92.
Formula:
C₁₉H₁₆N₂O₂ MW: 304,349 g/mol |
MDL Number:
MFCD06407798 CAS Number: 170632-47-0 |
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