5Z-7-Oxozeaenol (from Deuteromycetes sp.) ≥95% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

ALX380267M001 ALX380267M005
ENZOALX380267M001EA 82.1 GBP
ENZOALX380267M001 ENZOALX380267M005
5Z-7-Oxozeaenol (from Deuteromycetes sp.) ≥95% (by HPLC)
5Z-7-Oxozeaenol

Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor
>A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8nM) in an ATP-competitive and irreversible manner; also inhibits MEK1 (IC50 = 411nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) but at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells.


  • Protein kinase inhibitor


White to off-white solid.


Soluble in methanol, acetone, DMSO (up to 25mM) or ethyl acetate; insoluble in ethanol and n-hexane.

Formula: C₁₉H₂₂O₇
MW: 362,378 g/mol
Storage Temperature: Freezer
MDL Number: MFCD12912700
CAS Number: 66018-38-0

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