4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline ≥97% (by 1H-NMR)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
LY364947, 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline
ALX270448M001
ALX270448M005
ENZOALX270448M001EA
89.1
GBP
ENZOALX270448M001
ENZOALX270448M005
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline ≥97% (by 1H-NMR)
4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline
Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
Yellow to brown solid.
Soluble in DMSO or methanol.
Formula:
C₁₇H₁₂N₄ MW: 272,31 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00800758 CAS Number: 396129-53-6 |
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