VAS-2870 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine, VAS2870, 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)benzo[d]oxazole

BMLEI3950010 BMLEI3950050
ENZOBMLEI3950010EA 123 GBP
ENZOBMLEI3950010 ENZOBMLEI3950050
VAS-2870 ≥98% (by HPLC)
VAS-2870

Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).


  • NADPH oxidase inhibitor


White to off-white solid.


Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).

Formula: C₁₈H₁₂N₆OS
MW: 360,4 g/mol
Storage Temperature: Ambient
MDL Number: MFCD03407188
CAS Number: 722456-31-7
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