HNMPA-(AM)3 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
Hydroxy-2-naphthalenylmethylphosphonic acid tri-acetoxymethyl ester
HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
- Insulin receptor inhibitor
Colorless oil.
Soluble in DMSO (>20mg/ml) or 100% ethanol (>20mg/ml).
Formula:
C₂₀H₂₃O₁₀P MW: 454,4 g/mol Storage Temperature: Freezer |
CAS Number:
120944-03-8 |
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