Thiolutin (from Streptomyces luteosporeus) ≥95% (by HPLC, TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]-pyrrol-5(4H)-one
Sulfur containing antibiotic. Potent inhibitor of bacterial and yeast RNA polymerases. Inhibits mRNA chain elongation. Inhibits adhesion of endothelial cells (HUVECs) to vitronectin (IC50=0.83 µM) thereby inhibiting tumor cell-induced angiogenesis in vivo. Inhibits transcription in C. albicans. Inhibits microbiological growth in beer. Active against soil borne pathogens.
- RNA polymerase inhibitor
Yellow crystalline solid.
Soluble in DMSO (5mg/ml), very slightly soluble in water
Formula:
C₈H₈N₂O₂S₂ MW: 228,3 g/mol Storage Temperature: Freezer |
CAS Number:
87-11-6 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...