ZK-756326 ≥98% (by TLC), white solid

Supplier: ENZO LIFE SCIENCES AG

Synonyms: ZK 756326, 2-(2-(4-(3-Phenoxybenzyl)piperazin-1-yl)ethoxy)ethan-1-ol, 2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride

BMLCX1010010 BMLCX1010050
ENZOBMLCX1010010EA 121 GBP
ENZOBMLCX1010010 ENZOBMLCX1010050
ZK-756326 ≥98% (by TLC), white solid
ZK-756326

CCR8 activator.


Novel small molecule agonist at the CCR8 chemokine receptor (EC₅₀ = 254 nM) with no activity at CCR1, CCR2B, CCR4, CCR5, CXCR2, CXCR3 or CXCR4. Dose dependently increases intracellular calcium and stimulates extracellular acidification in cells expressing human CCR8. Murine CCR8-expressing cells underwent chemotaxis on exposure to this agonist. Inhibits HIV fusion of cells expressing CD4 and CCR8. Small molecule CCR8 agonists represent useful tools for exploring CCR8 biology especially in experiments where the use of the natural protein agonist is impractical.


Soluble in water (5 mg/ml) or DMSO (4 mg/ml).

Formula: C₂₁H₂₈N₂O₃·2HCl
MW: 429,38 g/mol
MDL Number: MFCD09038571
CAS Number: 874911-96-3
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Specification Test Results

Purity ≥98% (TLC)

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