CITCO
Supplier: ENZO LIFE SCIENCES AG
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Warning
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Synonyms:
6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime, 6-(4-Chlorophenyl)imidazo[2,1-b] [1,3]thiazole-5-carbaldehyde O-3,4-dichlorobenzyl) oxime
Constitutive androstane receptor ligand.
CITCO is a novel potent and selective agonist for the human orphan nuclear receptor CAR (constitutive androstane receptor). CITCO displayed an EC50 of 49 nM in a CAR FRET assay and showed 50-fold selectivity for CAR over PXR. CITCO displayed no activity against a panel of 15 other nuclear receptors at a concentration of 10 µM. In hepatocytes CITCO induced CAR nuclear translocation and induced the CAR target gene CYP2B6.
Soluble in DMF (25 mg/ml) or DMSO (10 mg/ml).
Formula:
C₁₉H₁₂Cl₃N₃OS MW: 436,7 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00139608 CAS Number: 338404-52-7 |
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