Parthenolide ≥97% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
4,5alpha-Epoxy-6beta-hydroxygermacra-1(10),11(13)-dien-12-oic Acid gamma-Lactone, (3aS,9aR,10aR,10bS,E)-6,9a-Dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one
HDAC inhibitor
Sesquiterpene lactone. Widely used as an herbal remedy for arthritis and migraine. Has anti-inflammatory, antisecretory and spasmolytic activity. Specifically inhibits activation of NF-kappaB by preventing the degradation of IkappaBalpha and IkappaBbeta. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs. Inhibits tubulin carboxypeptidase (TCP) activity.
Isolated from feverfew (Chrysanthemum parthenium) leaves.
Formula:
C₁₅H₂₀O₃ MW: 248,32 g/mol |
MDL Number:
MFCD00134592 CAS Number: 20554-84-1 |
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