Sulpho-NHS (N-Hydroxysulphosuccinimide sodium salt), Premium Grade, Pierce™
Supplier: Thermo Fisher Scientific
Synonyms:
N-Hydroxy sulphosuccinimide sodium salt, Hydroxy-2,5-dioxopyrrolidine-3-sulphonic acid sodium salt, N-Hydroxysulphosuccinimide sodium salt, Sulfo NHS, Sulpho-N-Hydroxysuccinimide
Thermo Scientific Pierce Premium Grade Sulfo-NHS is our highest quality formulation of this N-hydroxysuccinimide chemical modification reagent, specially characterized for applications where product integrity and risk minimization are paramount.
- Sulfo-NHS—use with EDC crosslinker to prepare amine-reactive NHS ester reagents
- High quality—identity and purity confirmed by several tests, including quantitative NMR
- Product integrity—enhanced level of testing and characterization compared to standard grade
- Lot retention—ample supply of past lots retained to ensure future process testing
- Change management—Change Control Notification (CCN) service
- Consistent manufacture—batch-specific manufacturing documentation review
Compared to the standard grade product, Premium Grade Sulfo-NHS provides more clearly defined quality and product support by including (a) increased analytical testing and product characterization, (b) greater batch-specific information and quality assurance review, (c) extensive lot sample retention and (d) change control notification. Sulfo-NHS (N-hydroxysulfosuccinimide) enables control and modification of carbodiimide crosslinking reactions involving activation of carboxylates (—COOH) for conjugation with primary amines (—NH2). Derivatives are easily synthesized by mixing the sulfo-NHS with a carboxyl-containing molecule and a dehydrating agent such as the carbodiimide EDC (EDAC). The method is the basis for generating many types of protein labeling reagents, including amine-reactive fluorescent dyes, biotin affinity tags and pegylation compounds.
Caution: For Research Use Only. Not for use in diagnostic procedures.
Formula:
C₄H₄NNaO₆S MW: 217,13 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00043100 CAS Number: 106627-54-7 |
Specification Test Results
Product Line | Pierce™ |
Labeling Method | Chemical Labeling |
Crosslinker Type | Heterobifunctional |
Reactive Moiety | Carbodiimide |
Spacer | Short |
Form | Powder |
Quantity | 500 mg /10 g |
Type | Crosslinker |
Solubility | Water |
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