Toluene-α-sulphonyl fluoride, white to off white needle crystals

Supplier: MP Biomedicals
Danger

Synonyms: α-Toluenesulphonyl fluoridePMSFPhenylmethylsulphonyl fluoridePhenylmethanesulphonyl fluoride

ICNA0219538180EA 959 GBP
ICNA0219538180 ICNA0219538125 ICNA02195381.2 ICNA0219538105 ICNA0219538101
Toluene-α-sulphonyl fluoride, white to off white needle crystals
Toluene-α-sulphonyl fluoride

Phenylmethylsulfonyl fluoride is an irreversible inhibitor of serine proteases - inhibits trypsin, chymotrypsin and protease. Inhibits mammalian acetyl cholinesterase, but not those from fish sources.


  • Presentation: White to off white needle crystals
  • Causes sulfonylation of the active-site serine residue
  • A less toxic substitute for the extremely toxic diisopropylfluorophosphate


Phenylmethylsulfonyl fluoride inhibits serine proteases such as trypsin and chymotrypsin. Also inhibits cysteine proteases (reversible by reduced thiols) and mammalian acetylcholinesterase.
Administration of PMSF produces analgesia unrelated to its anticholinesterase effect, and prolongs the analagesic effect of centrally administered β-endorphin.


Soluble in methanol and ethanol

Formula: C₇H₇FO₂S
MW: 174,2 g/mol
Melting Pt: 89…99 °C
Storage Temperature: Refrigerator
MDL Number: MFCD00007424
CAS Number: 329-98-6
EINECS: 206-350-2
UN: 2928
ADR: 6.1,II

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