Purvalanol A ≥98%, crystalline solid
Supplier: Cayman Chemical
Synonyms:
6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine, (R)-2-((6-((3-Chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.
Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death. At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.
Caution: Not for human or veterinary use.
Formula:
C₁₉H₂₅N₆OCl MW: 388,9 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD02179211 CAS Number: 212844-53-6 |
Specification Test Results
Purity | ≥98% |
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