EPZ-5676 (Pinometostat) ≥98%

Supplier: Cayman Chemical

Synonyms: (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(((cis-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol, Pinometostat

16175-10 16175-1 16175-25 16175-5
CAYM16175-10EA 466 GBP
CAYM16175-10 CAYM16175-1 CAYM16175-25 CAYM16175-5
EPZ-5676 (Pinometostat) ≥98%
Pinometostat (EPZ-5676)

EPZ5676 is a highly potent aminonucleoside inhibitor of DOT1 l histone methyltransferase activity (Ki = 80 pM) that demonstrates 37000-fold selectivity over other methyltransferases.


It can selectively inhibit the proliferation of acute leukemia cell lines bearing MLL translocations (IC50s range from 3.5 nM - 1.3 µM).

Formula: C₃₀H₄₂N₈O₃
MW: 562,71 g/mol
Storage Temperature: Freezer
MDL Number: MFCD24849415
CAS Number: 1380288-87-8

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Specification Test Results

Purity ≥98%
Formulation A Crystalline Solid
λmax 255 nm

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