6-OAU ≥98%
Supplier: Cayman Chemical
Synonyms:
6-(Octylamino)pyrimidine-2,4(1H,3H)-dione, 6-(octylamino)-2,4(1H,3H)-pyrimidinedione
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS.
- Formulation: A crystalline solid
- λmax: 265 nm
- Stability: 2 years at -20°C
6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.
Formula:
C₁₂H₂₁N₃O₂ MW: 239,30 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD28900678 CAS Number: 83797-69-7 |
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