Nα-(p-Toluenesulphonyl)-DL-lysine chloromethyl ketone hydrochloride ≥95% (by elemental analysis), off-white solid, Calbiochem®
Supplier: Merck Millipore Calbiochem
Synonyms:
Nα-p-Tosyl-DL-lysine chloromethyl ketone hydrochloride, TLCK
Inhibits trypsin-like serine proteinases.
Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC₅₀=80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
Formula:
C₁₄H₂₂Cl₂N₂O₃S MW: 369,31 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00012513 CAS Number: 4238-41-9 |
Specification Test Results
Purity (Elemental Analysis) | ≥95% |
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