2,3',4,5'-Tetramethoxystilbene ≥98%
Supplier: Cayman Chemical
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Warning
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Synonyms:
TMS, (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene
TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM.
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolises both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons.
It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 µg/ml.
Formula:
C₁₈H₂₀O₄ MW: 300,354 g/mol Melting Pt: -99 °C Storage Temperature: Freezer |
MDL Number:
MFCD03428621 CAS Number: 24144-92-1 |
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