Adapalene ≥98%

Supplier: Cayman Chemical

Synonyms: 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic Acid, 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

13655-100 13655-250 13655-500 13655-1
CAYM13655-100EA 283 GBP
CAYM13655-100 CAYM13655-250 CAYM13655-500 CAYM13655-1
Adapalene ≥98%
Adapalene

Adapalene, a synthetic naphthoic acid derivative, is a selective agonist of retinoic acid receptor (RAR)-β and RAR-γ (Kds = 34 and 130 nM, respectively). At 0,1-10 µM, adapalene dose-dependently inhibits sebocyte growth, proliferation and differentiation in a primary rat preputial cell culture system. Adapalene demonstrates anti-inflammatory and immunomodulatory activity by inhibiting 5-lipoxygenase-catalyzed leukotriene production and expression of toll-like receptor 2 on human monocytes. It is commonly used for the study of the pathogenesis and treatment of acne vulgaris.

Formula: C₂₈H₂₈O₃
MW: 412,53 g/mol
MDL Number: MFCD03106112
CAS Number: 106685-40-9

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