(12Z)-9,10-Dihydroxy-12-octadecenoic acid ≥98.0%

Supplier: Cayman Chemical

Synonyms: (9R,10R,12Z)-9,10-Dihydroxy-12-octadecenoic acid, (+/-)-Threo-9,10-dihydroxy-12(Z)-octadecenoic acid, Leukotoxin diol, (±)9(10)-DiHOME

53400-25 53400-50 53400-100 53400-500
CAYM53400-25EA 54.3 GBP
CAYM53400-25 CAYM53400-50 CAYM53400-100 CAYM53400-500
(12Z)-9,10-Dihydroxy-12-octadecenoic acid ≥98.0%
(12Z)-9,10-Dihydroxy-12-octadecenoic acid

Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME. Mitochondrial dysfunction, vasodilation and apoptosis are features of leukotoxin toxicity. In renal phydrolysesroximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.

Formula: C₁₈H₃₄O₄
MW: 314,466 g/mol
CAS Number: 263399-34-4

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Specification Test Results

Purity ≥98%
Formulation A solution in methyl acetate
Storage −20 °C
Stability 1 year from the QC date provided

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