(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®

Supplier: Merck Millipore Calbiochem

Synonyms: 6-Bromoindirubin-3'-oximeBIO(2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one6BIO

361550-30MGEA 2180 GBP
361550-30MG 361550-1 361550-10MG
(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®
(2'Z,3'E)-6-Bromoindirubin-3'-oxime

A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM).


Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells.

Formula: C₁₆H₁₀BrN₃O₂
MW: 356,18 g/mol
MDL Number: MFCD08705318
CAS Number: 667463-62-9

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