Y-27632 dihydrochloride

Supplier: Cayman Chemical

Synonyms: Y-27632 2HCl, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride, Rock inhibitor y-27632, trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride

10005583-1 10005583-10 10005583-5 10005583-50
CAYM10005583-1EA 95.9 GBP
CAYM10005583-1 CAYM10005583-10 CAYM10005583-5 CAYM10005583-50
Y-27632 dihydrochloride
Y-27632 dihydrochloride

Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nm) and ROCK-II (IC50 = 800 nm). It also inhibits PRK2 with an IC50 value of 600 nm.


  • Crystalline solid
  • Purity ≥98%
  • Storage at −20 °C


One-hour treatment with 10 µm Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passage.

Formula: C₁₄H₂₁N₃O·2HCl
MW: 320,26 g/mol
MDL Number: MFCD03490488
CAS Number: 129830-38-2 | 146986-50-7 (free base)

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