Anti-IDH1 Mouse Monoclonal Antibody (CF647) [clone: IDH1/1152]

Supplier: Biotium

BNC471152-500 BNC471152-100
BNC471152-500EA 510 GBP
BNC471152-500 BNC471152-100
Anti-IDH1 Mouse Monoclonal Antibody (CF647) [clone: IDH1/1152]
Antibodies
This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, formingalpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production ofalpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

Type: Primary
Antigen: IDH1
Clonality: Monoclonal
Clone: IDH1/1152
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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