(S)-(+)-Camptothecin ≥97%, pale yellow solid
Supplier: MP Biomedicals
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Danger
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Synonyms:
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (+)-Camptothecin, 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA.
- Binds irreversibly
- Blocks cell cycle
- Induces apoptosis
- Optical rotation: -139.5 ° (10 mg/mL, pyridine, 25 °C) (Lit.)
- Refractive index: n20D 1.75 (Lit.)
The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I
Camptothecin used to study transbilayer phospholipid movements by inducing apoptosis in EBV transformed B lymphocytes from ABCA1-Deficient Cells. Although most noted for its anticancer activity, Camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
Blocks the cell cycle in S-phase at low doses and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
EmM = 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm) (Lit.)
Soluble in DMSO (10 mg/mL), a chloroform:methanol mixture (8:2) or 1 N Sodium hydroxide (approximately 50 mg/mL). Creates a suspension in methanol (40 mg/mL).
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Formula:
C₂₀H₁₆N₂O₄ MW: 348,36 g/mol Melting Pt: 264…267 °C (lit.) Density: 1,51 g/cm³ (lit.) Flash Pt: 411,63 °C (lit.) Storage Temperature: Refrigerator |
MDL Number:
MFCD00081076 CAS Number: 7689-03-4 UN: 1544 ADR: 6.1,III |
Specification Test Results
| Identity Test | Passes |
| Purity | ≥97% |
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