Doxorubicin hydrochloride
Supplier: MP Biomedicals
Synonyms:
(8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
, Doxorubicin HCl
, Hydroxydaunorubicin Hydrochloride
Doxorubicin Hydrochloride is a chemotherapeutic, antitumour, immunosuppressive, and antibiotic agent.
Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis. Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localisation of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.
Fluorescence: Emmax: 585 nm (Exc.: 470 nm in ethanol) (Lit.).
Soluble in water (> 10 mg/ml), in isotonic sodium chloride, methanol, aqueous alcohols, DMSO (>10 mg/ml); practically insoluble in chloroform, ether, and other organic solvents.
Formula:
C₂₇H₂₉NO₁₁·HCl MW: 579,98 g/mol |
MDL Number:
MFCD00077757 CAS Number: 25316-40-9 |
Specification Test Results
Form | Reddish Orange Powder |
Storage | Store at Room Temperature (15 - 30 °C) |
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