Tamoxifen citrate, white powder

Supplier: MP Biomedicals

Synonyms: (Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate

0215673980 0215673983 0215673991
ICNA0215673980EA 39.6 GBP
ICNA0215673980 ICNA0215673983 ICNA0215673991
Tamoxifen citrate, white powder
Tamoxifen citrate

Tamoxifen has been shown to protect bone from estrogen-deficiency bone loss and lower plasma cholesterol in the rat. A 10 µM solution has exhibited fungicidal activity (optimal pH 7,5) against yeast cells of C. albicans. It has been implemented in liver carcinogenesis in rats.


Other actions of tamoxifen are: Reduction of plasma levels of insulin-like growth factor; Induction of cells surrounding cancer cells to secrete transforming growth factor b; Inhibition of membrane lipid peroxidation probably by decreasing membrane fluidity.


Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.


Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0,3 mg/L at 20 °C; the pH is approximately 3,0 to 3,5), 0,02 N HCl (0,2 mg/ml at 37 °C), acetone or chloroform.

Formula: C₂₆H₂₉NO
MW: 563,65 g/mol
MDL Number: MFCD00058321
CAS Number: 54965-24-1

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