Desmosine 99%, yellow solid

Supplier: MP Biomedicals

Synonyms: 4-[(4S)-4-AMino-4-carboxybutyl]-1-[(5S)-5-aMino-5-carboxypentyl]-3,5-bis[(3S)-3-aMino-3-carboxypropyl]pyridiniuM, 2-amino-6-[4-(4-amino-4-carboxy-butyl)-3,5-bis(3-amino-3-carboxy-propyl)pyridin-1-yl]hexanoic acid, ELA Desmosine

0219137805 0219137801
ICNA0219137805EA 589 GBP
ICNA0219137805 ICNA0219137801
Desmosine 99%, yellow solid
Desmosine

Desmosine is prepared according to the method of Starcher et al. from hydrolysed neck ligament by solvent extraction and chromatography on Dowex 50.


NOTE: Extremely hygroscopic and must be stored over a desiccant such as silica gel.


Desmosine is a tetrafunctional, pyridinium ring-containing amino acids involved in elastin cross-linking. A desmosine cross-link is formed from three allysyl side chains plus one unaltered lysyl side chain from the same or neighbouring polypeptides.


Desmosine is responsible for the cross-linking of elastin leading to the formation of insoluble fibers. Urinary excretion of desmosine is a useful indicator of elastin breakdown resulting from increased elastase activity. It also acts as a biomarker of elastin degradation in chronic obstructive.


Caution: Research Use Only (RUO). Extremely hygroscopic and must be stored over a desiccant such as silica gel.

Formula: C₂₄H₃₉N₅O₈
MW: 526 g/mol (anhy)
Storage Temperature: Refrigerator
CAS Number: 11003-57-9

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Specification Test Results

Identity Test Passes
Source Bovine Neck Ligament
Purity 99%

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