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Product Image-CPSDAM450/100

Nylon webbing sling, Protecta®, DBI-SALA®, 3M™

Catalog Number: (CPSDAM450/100)
Supplier: CAPITAL SAFETY
Description: Polyester webbing slings are made from top quality materials guaranteeing high strength and durability. Can be used as versatile temporary anchorage solution.
UOM: 1 * 1 items
Product Image-MMMA1500047

Hook2Loop Bungee tool tether, DBI-SALA®, 3M™

Supplier: CAPITAL SAFETY
Description: Bungee tool tether with self-locking carabiner.

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Image Unavailable-BOSSBS-6669R-A350

Anti-ID4 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-6669R-A350)
Supplier: Bioss
Description: Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (1–3), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (1–5). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6669R-A555

Anti-ID4 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-6669R-A555)
Supplier: Bioss
Description: Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1 (1–3), Id2 (4), Id3 and Id4 (5). They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins (1–5). Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12260R-FITC

Anti-PSMA4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-12260R-FITC)
Supplier: Bioss
Description: The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. All of the subunits fall into one of two types: alpha subunits, which are structural, serve as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity; or beta subunits, which are predominantly catalytic. The outer two rings in the proteasome consist of seven ?subunits each, and the inner two rings each consist of seven beta subunits.
UOM: 1 * 100 µl
Product Image-CPSD3504555

Self-retracting lifelines Ultra-Lok™, DBI-SALA®, 3M™

Catalog Number: (CPSD3504555)
Supplier: CAPITAL SAFETY
Description: Ultra-Lok™ web and cable SRLs are rugged, highly engineered devices that can be counted on for user safety, efficiency and reliability. Available with synthetic rope, stainless steel or galvanised steel cable and aluminium or thermoplastic housing.
UOM: 1 * 1 items
Product Image-113-8669

Safety device against suspension trauma, Miller Relief Step™ Safety Device

Catalog Number: (113-8669)
Supplier: HONEYWELL SAFETY
Description: The Miller Relief Step™ Safety Device alleviates the effects of orthostatic intolerance, also known as suspension trauma. If a fall occurs, a person becomes suspended in a harness and remains both vertical and sedentary for a period of time, causing blood to ‘pool’ in the veins of the legs. Subsequently, blood flow is restricted to the brain and other major organs that may initially result in unconsciousness. If not rescued promptly, serious injury or death may occur. The Miller Relief Step is designed to provide a short-term solution in preventing suspension trauma.
UOM: 1 * 1 items
Product Image-DALL1003099

Miller® Reglex Lanyard

Catalog Number: (DALL1003099)
Supplier: HONEYWELL SAFETY
Description: Reinforced lanyard for work positioning, suitable for tree work. The tree worker uses the lanyard together with climbing spurs to climb the tree trunk.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-10438R-A750

Anti-B3GALNT1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-10438R-A750)
Supplier: Bioss
Description: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesised by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein.
UOM: 1 * 100 µl
Product Image-MMMAAM450/80

Sling polyester webbing, Protecta®, 3M™

Catalog Number: (MMMAAM450/80)
Supplier: 3M
Description: The Protecta® Nylon Webbing Sling Anchor features four safety seams, and measures 80 cm in length.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-3812R-A750

Anti-NEDD8 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-3812R-A750)
Supplier: Bioss
Description: Ubiquitin like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin, RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other. In contrast to UBLs, UDPs are not proteolytically processed or conjugated to other proteins. Rub1 and the corresponding human homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, that forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to ubiquitin. The best known targets of Rub1 modification are members of the cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification may regulate SCF function or localization.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10438R-A647

Anti-B3GALNT1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-10438R-A647)
Supplier: Bioss
Description: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3812R-A555

Anti-NEDD8 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-3812R-A555)
Supplier: Bioss
Description: Ubiquitin like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin. Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg12 and Hub1. Proteins of the second class include Parkin, RAD23 and DSK2, are designated ubiquitin domain proteins (UDPs). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other. In contrast to UBLs, UDPs are not proteolytically processed or conjugated to other proteins. Rub1 and the corresponding human homolog NEDD8 are activated by the E1 ubiquitin activating enzyme UBA2, that forms isopeptide linkages between thio esters. NEDD8 shows 80% homology to ubiquitin. The best known targets of Rub1 modification are members of the cullin family. Cullins are subunits of an E3 ubiquitin ligase complex called the Skp1 /Cul1/Cdc53 F box (SCF). The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein. Rub1 modification may regulate SCF function or localization.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9430R-CY5.5

Anti-HSPB7 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-9430R-CY5.5)
Supplier: Bioss
Description: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting.
UOM: 1 * 100 µl
Product Image-DALL1002927

Tree-pruning harness

Catalog Number: (DALL1002927)
Supplier: HONEYWELL SAFETY
Description: Commonly used in conjunction with a climbing line, spikes and a work-positioning lanyard, these 2-point full body harnesses are suitable for heavier tree-pruning operations, for example when using a chainsaw. They feature a positioning belt, seat strap, rear anchorage for fall arrest and a sternal anchorage for the climbing line.
UOM: 1 * 1 items
Product Image-CPSDAM210

Fixed anchorage plate, Protecta, 3M™

Catalog Number: (CPSDAM210)
Supplier: CAPITAL SAFETY
Description: Protecta® Fixed anchorage plate made from stainless steel.
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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