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Image Unavailable-PRSI92-149

Human recombinant Carbonic Anhydrase 14 (from E. coli)

Catalog Number: (PRSI92-149)
Supplier: ProSci Inc.
Description: Carbonic Anhydrase 14 (CA14) belongs to the Alpha-Carbonic Anhydrase family. It is highly expressed in all parts of the central nervous system and lowly expressed in adult liver, heart, small intestine, colon, kidney, urinary bladder, and skeletal muscle. CA14 along with other Carbonic Anhydrases (CAs) participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA14 is predicted to be a type I membrane protein and catalyses the reversible hydration of carbon dioxide.
UOM: 1 * 50 µG
Image Unavailable-PRSI90-313

Human recombinant Frizzled-5 (from HEK293 cells)

Catalog Number: (PRSI90-313)
Supplier: ProSci Inc.
Description: Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signalling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signalling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.
UOM: 1 * 50 µG
Image Unavailable-PRSI91-662

Human recombinant Dihydropteridine Reductase (from cells)

Catalog Number: (PRSI91-662)
Supplier: ProSci Inc.
Description: Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) which is a rare autosomal recessive disorder and is lethal.
UOM: 1 * 50 µG
Product Image-231-0637

Sampling scoops with lid, Sterileware®, SP Bel-Art

Supplier: Bel-Art Products, a Part of SP
Description: White PS. These scoops made of high-impact FDA grade PS feature a detachable lid. They eliminate the cost of separate sterile bags or containers, saving you time and money in your sample collection process.

Certificates

Product Image-113-8337

Beard cover, Hopen®

Catalog Number: (113-8337)
Supplier: Medicom
Description: This disposable beard cover made of white PP covers the lower part of the face. It is HACCP approved and therefore ideal for use in food applications, such as catering and food processing. Also suitable for chemical, pharmaceutical and maintenance applications.
UOM: 1 * 100 items
Product Image-PRSI30-150

Anti-MMP7 Rabbit Polyclonal Antibody

Catalog Number: (PRSI30-150)
Supplier: ProSci Inc.
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP7 degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
UOM: 1 * 100 µG
Product Image-PRSI36-322

Anti-NLRP1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI36-322)
Supplier: ProSci Inc.
Description: NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
UOM: 1 * 100 µG
Product Image-J850-5KG

VWR®, Yeast extract

Supplier: VWR Chemicals
Description: Yeast extract is the water soluble portion of autolysed yeast containing a source of Vitamin B complex.

MSDS Certificates

Image Unavailable-PRSI91-164

Human recombinant UBE2D4 (from E. coli)

Catalog Number: (PRSI91-164)
Supplier: ProSci Inc.
Description: Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process. UBE2D4 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2D4 able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked poly-ubiquitination.
UOM: 1 * 50 µG
Product Image-181-0310

VWR® VP 220, Chemical Duty, High Performance Diaphragm Pump

Catalog Number: (181-0310)
Supplier: VWR Collection
Description: The VP 220 is ideal for rotary evaporators providing the powerful vacuum needed for demanding evaporations without the use of oil pumps. VP 220 has built-in Advanced Vapour Management (AVM) which means precise control capability for the distillation of organic solvents and applications handling aggressive vapours and gases. The VP 220 is especially effective for rotary evaporation of low boiling point solvents such as acetone and ethanol and is able to rapidly strip DMF at 35 °C. The pump parts are all made of corrosion resistant materials such as PTFE and Kalrez to handle aggressive vapours, and together with vacuum adjustment, the evaporation process will be optimised. Use the vacuum adjustment to increase the vacuum until bubbles form in the evaporation flask - then lower it slightly. Reduce the vacuum for fast reaction to bumping or foaming.
UOM: 1 * 1 items
Image Unavailable-SPCMMA147-500GM

DL-Malic acid ≥99.0% FCC

Catalog Number: (SPCMMA147-500GM)
Supplier: Spectrum Chemical
Description: Malic Acid, FCC is used as a source of extreme tartness. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
UOM: 1 * 500 g
Product Image-PRSIXW-7880

Anti-GAR1 Chicken Polyclonal Antibody

Catalog Number: (PRSIXW-7880)
Supplier: ProSci Inc.
Description: FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
UOM: 1 * 50 µG
Product Image-PRSI29-275

Anti-HNRNPL Rabbit Polyclonal Antibody

Catalog Number: (PRSI29-275)
Supplier: ProSci Inc.
Description: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions.Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
UOM: 1 * 50 µG
Image Unavailable-ICNA0204569

Alumina B, activity super I, white to light pink free flowing powder, MP EcoChrom™ for dioxin analysis

Catalog Number: (ICNA0204569)
Supplier: MP Biomedicals
Description: MP EcoChrom™ Alumina, Activity Super I is essentially aluminum oxide, Al2O3, occurring in nature as minerals bauxite, bayerite, corundum, etc. This product meets the high recovery level required for the analysis of polychlorinated dibenzodioxins and dibenzofurans according to VDI Regulation 3499, part I.
MP EcoChrom™ Alumina B, Activity Super I is used for Dioxin analysis. It also been used for all chromatographic processes requiring highest activity and/or highest reproducibility.
Store at Room Temperature (15-30 °C)
UOM: 1 * 500 g

MSDS Certificates


Product Image-BELAH372600100

Mini mortar with pestle, SP Bel-Art

Catalog Number: (BELAH372600100)
Supplier: Bel-Art Products, a Part of SP
Description: Freeze and process small tissue samples within a microcentrifuge tube. Stainless steel mortar has a welded fixture to hold a 1,5ml microcentrifuge tube. The mortar is suspended above a stainless steel cavity which holds the liquid nitrogen and is nested in a heavily insulated blue polyethylene housing.
UOM: 1 * 1 items
Image Unavailable-PRSI92-023

Human recombinant Toll-Interacting (from E. coli)

Catalog Number: (PRSI92-023)
Supplier: ProSci Inc.
Description: Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins. TOLLIP can negative regulate Toll-like receptors signaling, which may limit the production of proinflammatory mediators during the process of inflammation and infection.
UOM: 1 * 50 µG
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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